Assessing factors related to change the anti - diphtheria IgG antibodies in the age group from 5 to 40 in Khanh Hoa province in 2022

Authors

  • Nguyễn Đình Lượng Pasteur Institute in Nha Trang, Khanh Hoa
  • Đào Thế Anh Pasteur Institute in Nha Trang, Khanh Hoa
  • Hoàng Tiến Thanh Pasteur Institute in Nha Trang, Khanh Hoa
  • Nguyễn Bảo Triệu Pasteur Institute in Nha Trang, Khanh Hoa
  • Huỳnh Kim Mai Pasteur Institute in Nha Trang, Khanh Hoa
  • Lê Xuân Huy Pasteur Institute in Nha Trang, Khanh Hoa
  • Lê Thùy Liên Pasteur Institute in Nha Trang, Khanh Hoa
  • Nguyễn Thành Đông Pasteur Institute in Nha Trang, Khanh Hoa
  • Nguyễn Tất Hòa Pasteur Institute in Nha Trang, Khanh Hoa
  • Lê Hoàng Thiệu Pasteur Institute in Nha Trang, Khanh Hoa
  • Đoàn Thị Thanh Thủy Pasteur Institute in Nha Trang, Khanh Hoa
  • Trương Gia Linh Pasteur Institute in Nha Trang, Khanh Hoa
  • Lê Hồng Quân Khanh Hoa Oncology Hospital
  • Trần Bình Thắng Department of Public Health, Hue University of Medical and Pharmacy
  • Lay Myint Yoshida Nagasaki University, Japan
  • Đỗ Thái Hùng Pasteur Institute in Nha Trang, Khanh Hoa

DOI:

https://doi.org/10.51403/0868-2836/2023/1404

Keywords:

The anti - diphtheria IgG antibodies, related to, ROC curve, Khanh Hoa

Abstract

Diphtheria is a disease that can be prevented with a vaccine containing the diphtheria component, in recent years, there have been sparse outbreaks of disease in Vietnam’s Central region. The study included 1.195 participants aged 5 - 40 in Khanh Hoa province to determine immune levels status and factors affecting anti-diphtheria toxin IgG antibodies. ROC curve analysis was used to predict the model’s effectiveness by assessing the area under the curve (AUC). The results indicated that the 5 - 10 age group had the highest safety protection threshold at 34.48%. With an AUC of 71.1% (95% CI [67.8% - 74.5%], p < 0.001); sensitivity of 55.8%; and specificity of 76.5%, the ROC curve analysis suggested classifying factors influencing IgG antibody response to diphtheria toxin, including BMI (OR = 0.96), age group (the lowest in the 11 - 20 age group (OR = 0.18)), and the living area. Early intervention strategies by diphtheria-containing vaccines are needed to protect the community with each age group and geographical area in the province.

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Published

26-01-2024

How to Cite

Lượng, N. Đình ., Anh, Đào T. ., Thanh, H. T. ., Triệu, N. B. ., Mai, H. K. ., Huy, L. X. ., Liên, L. T. ., Đông, N. T. ., Hòa, N. T. ., Thiệu, L. H. ., Thủy, Đoàn T. T. ., Linh, T. G. ., Quân, L. H. ., Thắng, T. B. ., Yoshida, L. M. ., & Hùng, Đỗ T. . (2024). Assessing factors related to change the anti - diphtheria IgG antibodies in the age group from 5 to 40 in Khanh Hoa province in 2022. Vietnam Journal of Preventive Medicine, 33(6 Phụ bản), 79–87. https://doi.org/10.51403/0868-2836/2023/1404

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