Stability of oral bivalent polio vaccine produced in Vietnam

Authors

  • Phùng Thị Tươi Center for Research and Production of Vaccines and Biologicals
  • Trần Thị Bích Hạnh Center for Research and Production of Vaccines and Biologicals
  • Nguyễn Thúy Hường Center for Research and Production of Vaccines and Biologicals
  • Nguyễn Đăng Hiền Center for Research and Production of Vaccines and Biologicals

DOI:

https://doi.org/10.51403/0868-2836/2020/136

Keywords:

bOPV, potency, WHO

Abstract

Center for Research and Production of Vaccines and Biologicals has produced bOPV from 2017, an oral, live attenuated bivalent Polio vaccine according to the recommendation of WHO and Ministry of Health of Vietnam. This study aims to determine stability of oral bivalent polio vaccine produced in Vietnam in the conditions of 2 - 8°C and -20°C. bOPV is produced with the same ingredients as tOPV, but without Polio virus type 2. By micro neutralization method on Hep2C cells, we have
determined that potency of bOPV is stable at storage condition -20°C up to 42 months, 2 - 8°C upto 9 months. Thermostability of vaccine incubated at 37oC/24 h in both 2 storage condition is decreased not more than 0,6 lgCCID50 /0,1ml in comparison with that stored at -20oC. With the study results, we propose the shelf life for bOPV is 36 months.

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Published

26-04-2021

How to Cite

Tươi, P. T. ., Hạnh, T. T. B. ., Hường, N. T. ., & Hiền, N. Đăng . (2021). Stability of oral bivalent polio vaccine produced in Vietnam. Vietnam Journal of Preventive Medicine, 30(8), 66–73. https://doi.org/10.51403/0868-2836/2020/136

Issue

Vol. 30 No. 8 (2020): SỐ THƯỜNG KÌ

Section

Original Papers

License

Publication License No 150/GP-BTTTT signed on May 8, 2014;
Electronic Publication License No 322/GP-BTTTT signed on June 15, 2016.

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