Stability study of rotavin vaccine new formulation produced in Vietnam

Abstract

Center for Research and Production of Vaccines and Biologicals conducted this study aims to evaluate the stability of rotavin
vaccine new formulation produced in Vietnam the Rotavin vaccine new formulation was added with Hydrolyzed gelatin as stabilizer to maintain the stability of vaccine in storage condition at 2-8oC, for introducing Rotavin vaccine with conveniently storage and distribution the vaccine in the National Expanded Immunization Program. The PFU method was used to determine the titer of the Rotavin vaccine new formulation stored under accelerated temperature at 37°C, 25°C and realtime storage temperature at 2-8°C at different time points from date of manufacture. The results showed that Rotavin vaccine having stable titer for 7 days at 37oC, for 45 days at 25oC and for 24 months at 2-8oC.