Mother-to-child transmission of the hepatitis B virus and related factors among pregnant woman with HbsAg positive in Hai Phong Hospital of Obstetrics and gynecology, 2017 - 2019

Abstract

A follow-up study clarifying conducted between October 2017 and December 2019 on 183 HBsAg - positive pregnant women
managing pregnancy, giving birth at Hai Phong Obstetrics Hospital, then follow up to 12 months postpartum to determine the rate of transmission of hepatitis B virus from mother to child and describe some factors related to mother - to - child transmission. At 12 months after, the study tracked 150 mother - child pairs of an HBsAg-positive mother. The study
results showed rate of transmission mother to child is 8.0%; a high rate of transmission in the group of infants born to infected mother were HBeAg positive (34.5%); high HBV DNA load (> 200,000 IU/ml) 16.7%; family member infected with hepatitis B virus (21.7%); The children were vaccinated with the newborn hepatitis B vaccine (50%), the children were
vaccinated with HBIG after birth (18.5%), the children did not complete the hepatitis B vaccination schedule (25.0%). Factors
associated with mother - to - child transmission of the hepatitis B virus are maternal HBeAg status at birth; a family infected with hepatitis B virus, the child was vaccinated with HBIG after birth (p <0.05). Babies born to an HBeAg positive mothers had a 65.8 times higher risk of acquiring hepatitis B virus than children born to HBsAg-positive mothers only (OR: 65.8; 95 % CI: 7.3 - 594.1)