Distribution of single nucleotide polymorphism in LPLrs320 with the risk of dyslipidemia in middle-aged people in Ha Nam

Abstract

Dyslipidemia is one of the important factors for the formation and development of coronary and cerebrovascular diseases, the dangerous complications of which are atherosclerosis, myocardial infarction, stroke, and even death. The objective of the study is to determine the allele rate, genotype rate, and relationship between single nucleotide polymorphism rs320 (SNP rs320) on the lipoprotein lipase (LPL) gene and the risk of dyslipidemia in middle-aged people in Ha Nam. The study was designed as a case-control study. SNP rs320 was analyzed by allele-specific primers and Sanger sequencing to identify the T and G alleles. The study’s findings revealed that the TT, TG, and GG genotype rates were 55%, 37%, and 8%, respectively; the T and G allele rates of SNP rs320 were 73% and 27%, respectively. Following Hardy-Weinberg equilibrium, the allele distribution and genotype ratio distribution of single nucleotide polymorphism rs320 were comparable in the case group and control group. The study found no association between SNP rs320 and the risk of dyslipidemia in middle-aged people in Ha Nam.