Association of dyslipidemia with single nucleotide polymorphism rs2070895 of hepatic lipase (HL) gene in middle-aged Ha Nam population

Abstract

The study aimed to determine detetrmine the genotype and allele ratios of the single nucleotide polymorphism rs2072895 (SNP rs2070895) and the association between this SNP and dyslipidemia in middle-aged people in Ha Nam. A case-control study design was used to analyze the association between SNP rs2070895 and dyslipidemia. Genotypes at SNP rs2070895 analysis were determined by polymerase chain reaction using allele-specific primers. SNPrs2070895 was analyzed using the allele-specific primer polymerase chain reaction (AS-PCR). According to the study’s findings, the genotypes GG, GA, and AA were 38.8%, 45.0%, and 16.2%, respectively; the G and A allele ratios of SNP rs2070895 were 61% and 39% respectively. The HardyWeinberg equilibrium law was followed by the genotype distribution of SNP rs2070895. Increased total cholesterol, LDL-C, decreased HDL-C, and dyslipidemia were not associated with LIPCrs2070895 (p > 0.05). The risk of hypertriglyceridemia was impacted by the GA heterozygous genotype (p < 0.05). Those with the heterozygous GA genotype were more likely to experience hypertriglyceridemia than those with the homozygous AA and GG genotypes in the population.