Clinical and subclinical characteristics, treatment results of cutaneous adverse drug reactions at Viet Tiep Hospital from 2015 to 2020

Abstract

The objective of the study was to describe the clinical, subclinical characteristics and treatment results of patients with cutaneous adverse drug reactions (cADRs) at the Dermatology Department of Viet Tiep Hospital, from 2015 to 2020. The study design was a cross-sectional descriptive study in a group of 246 inpatients. The study results showed that 95.5% of patients had itching on admission, and 71.5% of patients had erythema as the initial symptom. 31.1% of cases were diagnosed as severe forms. 25.68% of patients admitted to the hospital showed signs of fever, of which 13.8% had a high fever ≥ 38.50C. There were 32.5% with mild neutrophilic leukocytosis. Enzyme AST, ALT normal in 85.1% of patients. The mean duration of treatment for all subjects was 7.9 days. Erythroderma had the longest treatment time of
14.5 days. 100% of patients with cADR were discharged from the hospital. 23.1% of patients with Lyell’s syndrome had severe progression to hospital. Conclusions: Itching and erythema are common initiating symptoms of cADR. Severe forms account for a lower proportion than normal ones, but the treatment time is longer.