Prevalence of congenital absence of vas deferens and related genetic factors among male infertilities: A systematic review

Các tác giả

  • Dang Tuan Anh Tam Anh General Hospital, Hanoi
  • Cao Tuan Anh Tam Anh General Hospital, Hanoi
  • Nguyen Huy Hoang Tam Anh General Hospital, Hanoi
  • Bui Thi Len Tam Anh General Hospital, Hanoi
  • Dang Tien Truong Vietnam Military Medical University, Hanoi
  • Le Hoang Tam Anh General Hospital, Hanoi
  • Tham Chi Dung Ministry of Health, Hanoi

DOI:

https://doi.org/10.51403/0868-2836/2020/123

Từ khóa:

CAVD, CFTR, CBAVD, CUAVD, ADGRG2

Tóm tắt

A systematic review was conducted to describe the prevalence of congenital absence of vas deferens (CAVD) and types of cystic fbrosis transmembrane conductance regulator (CFTR) gene mutation, Adhesion G-protein coupled receptor G2 (ADGRG2) mutation leading to CAVD among male infertilities aimed at providing comprehensive counseling in the treatment of male infertility. Information and data from eligible publications were searched and selected from the PubMed and Medline e-library from 2010 to 2020 by using 8 main keywords. The results showed that the prevalence of CAVD was approximately 0.1% in male and about 80% of congenital bilateral absences of the vas deferens (CABVD) patients had the CFTR mutation. These mutations were recessive gene abnormalities on the long arm of chromosome 7. Besides the mutation, recent researches showed the mutation of the ADGRG2 gene on X chromosome also led to CBAVD. It was approximately 10 - 20% of CBAVD and 60 - 70% of the congenital unilateral absence of the vas deferens (CUAVD) that was still not diagnosed genetically. In conclusion, the genetic consultation is necessary for CAVD patients before deciding to have a baby

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Đã Xuất bản

25-04-2021

Cách trích dẫn

Anh, D. T. ., Anh, C. T. ., Hoang, N. H. ., Len, B. T. ., Truong, D. T., Hoang, L. ., & Dung, T. C. . (2021). Prevalence of congenital absence of vas deferens and related genetic factors among male infertilities: A systematic review. Tạp Chí Y học Dự phòng, 30(9), 59–67. https://doi.org/10.51403/0868-2836/2020/123

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