Establishment of the national reference of measles vaccine

Abstract

National Institute for Control of Vaccine anh Biologicals controls quality of numorous batchs of measles containing vaccines annually whereas there isn’t any national reference standard for them available yet. With the purpose of establishing a batch of measles vaccines reference standard meets WHO requirements, National Institute for Control of Vaccine anh Biologicals has collaborated with Center for Research and Production of Vaccines and Biologicals to produce a candidate measles vaccines reference standard one. After producing, the candidate batch was controlled its quality, calibrated agains the international standard to assign the its. The result reveals that measles reference standard lot MCQG. SOI.01 meets the specifcation requirements
of a national standard, has potency at (3,49 ±
0,21) LgCCID50/0,5ml CCID50, has a self life
of more than 40 years.