The characteristics of thrombophilia gene mutations in women with history ofpregnancy loss at Hai Phong Hospital of Obstetrics and Gynecology, 2022 - 2023

Abstract

This study aims to describe the characteristics of thrombophilia gene mutations in women with history of pregnancy loss and some related factors. A cross-sectional study conducted on 205 women had history of pregnancy loss at Haiphong hospital of Obstetrics and Gynecology from 6/2022 to 5/2023. Describe the prevalence and characteristics of thrombophilia gene mutations and relationship between these mutations and pregnancy loss. Our findings showed that the prevalence of gene mutations included Factor V Leiden 0.5%; Factor V R2 6.8%; MTHFR 677 C/T 35.1%; MTHFR 1298 A/C 52.2%; prothrombin; PAI-1 79.0%. Having from 4 mutated alleles increases the risk of recurrent pregnancy loss 6,9 times, p < 0.001, OR = 6.9 (95% CI: 2.4 – 19.9). Women carrying Factor V R2 gene mutation have higher risk of recurrent pregnancy loss (p = 0.023). Incidence of MTHFR 1298 A/C gene mutation in study population is significantly higher than in general population but the difference in recurrent pregnancy loss ratio between groups of women with/without mutation is not statistically significant (p = 0.38). Therefore, thrombophilia gene mutations have a certain effect on the etiolody of recurrent pregnancy loss.