Antibiotic selection in early - onset neonatal infection at the National Hospital of Obstetrics and Gynecology in 2022

Abstract

The study was carried out at the National Hospital of Obstetrics and Gynecology to describe the characteristics of antibiotic selection in early - onset neonatal infection. This retrospective study was conducted on the medical records of 199 neonatal patients who received at least one systemic antibiotic at the Neonatal Care and Treatment Center from 1st October 2022 to 30th November 2022. The results show that 54.8% of patients were male; 65.3% of infants were born via cesarean section. The most common red flag signs relating earlyonset neonatal infection were: suspected or confirmed infection in another baby in the case of a multiple pregnancy (16.1%); need for mechanical ventilation in term infants (16.6%). 97.5% of patients who had at least two “non-red flags” or one “red flag” indicator were given empiric antibiotics. Ampicillin/ sulbactam + aminoside was used at a rate of 55.3%, while the rate for the single antibiotic regimen was 42.2%. A combined antibiotic regimen, as recommended in the guidelines for the treatment of neonatal infections, should be used.