TY - JOUR AU - Thao, Pham Thi Phuong AU - Mai, Chu Thi Ngoc AU - Ly, Le Thi Khanh AU - Anh, Lai Tuan AU - Thanh, Vu Duc AU - Mai, Le Thi Phuong AU - Quyet, Nguyen Tu AU - Mai, Tran Ngoc Phuong AU - Thiem, Vu Dinh AU - Hien, Nguyen Dang AU - Anh, Dang Duc AU - Trang, Nguyen Van PY - 2022/08/01 Y2 - 2024/03/29 TI - Prevalence of viral gastroenteritis pathogens among hospitalized children under 5 year of age in the process of introducing the RV vaccine in the routine immunization JF - Tạp chí Y học Dự phòng JA - TC YHDP VL - 32 IS - 4 SE - Bài báo nghiên cứu gốc DO - 10.51403/0868-2836/2022/686 UR - https://vjpm.vn/index.php/vjpm/article/view/686 SP - 74-81 AB - <p><span class="fontstyle0">Rotavirus (RV), Norovirus (NV), Sapovirus (SaV) and Astrovirus (Ast) are the leading causes of gastroenteritis and mortality in children worldwide. RV vaccines help to reduce the burden of diarrhea while the importance of other viruses is increasing. Therefore, we conducted a cross-sectional descriptive study to determine prevalence of these viruses in hospitalized children under 5 years old in Nam Dinh province with approximately 80% of RV vaccine coverage. We randomly selected 579 (25%) among diarrheal samples collected in 4 district hospitals from Dec. 2017 to Nov. 2019. An ELISA kit was employed to detect RV and the multiplex real-time RT-PCR with specific primers to detect NV, SaV and Ast. These viruses were found among 64.3% of hospitalized children, of which NV and RV were present in 28.5% and 21.4%, respectively, while SaV and Ast were detected in 3.3% and 2.6%, respectively. Co-infections accounted for 8.5%, mainly among RV and 3 other viruses. There is a significant difference in RV and NV positive rates between vaccinated and unvaccinated groups (p &lt; 0.001 and p = 0.008, respectively). This study contributed to the understanding of the potential impact of rotavirus vaccine on other diarheal pathogens and emphasize the need for further epidemiological studies when the nationwide RV vaccination in Vietnam is implementing.</span> </p> ER -