Prevalence of viral gastroenteritis pathogens among hospitalized children under 5 year of age in the process of introducing the RV vaccine in the routine immunization

Các tác giả

  • Pham Thi Phuong Thao Center for Research and Production of Vaccines and Biologicals (POLYVAC), Hanoi
  • Chu Thi Ngoc Mai National Institute of Hygiene and Epidemiology (NIHE), Hanoi
  • Le Thi Khanh Ly National Institute of Hygiene and Epidemiology (NIHE), Hanoi
  • Lai Tuan Anh Center for Disease Control and Prevention of Nam Dinh province
  • Vu Duc Thanh Center for Disease Control and Prevention of Nam Dinh province
  • Le Thi Phuong Mai National Institute of Hygiene and Epidemiology (NIHE), Hanoi
  • Nguyen Tu Quyet National Institute of Hygiene and Epidemiology (NIHE), Hanoi
  • Tran Ngoc Phuong Mai National Institute of Hygiene and Epidemiology (NIHE), Hanoi
  • Vu Dinh Thiem National Institute of Hygiene and Epidemiology (NIHE), Hanoi
  • Nguyen Dang Hien Center for Research and Production of Vaccines and Biologicals (POLYVAC), Hanoi
  • Dang Duc Anh National Institute of Hygiene and Epidemiology (NIHE), Hanoi
  • Nguyen Van Trang National Institute of Hygiene and Epidemiology (NIHE), Hanoi

DOI:

https://doi.org/10.51403/0868-2836/2022/686

Từ khóa:

Rotavirus, Norovirus, Astrovirus, Sapovirus, acute gastroenteritis

Tóm tắt

Rotavirus (RV), Norovirus (NV), Sapovirus (SaV) and Astrovirus (Ast) are the leading causes of gastroenteritis and mortality in children worldwide. RV vaccines help to reduce the burden of diarrhea while the importance of other viruses is increasing. Therefore, we conducted a cross-sectional descriptive study to determine prevalence of these viruses in hospitalized children under 5 years old in Nam Dinh province with approximately 80% of RV vaccine coverage. We randomly selected 579 (25%) among diarrheal samples collected in 4 district hospitals from Dec. 2017 to Nov. 2019. An ELISA kit was employed to detect RV and the multiplex real-time RT-PCR with specific primers to detect NV, SaV and Ast. These viruses were found among 64.3% of hospitalized children, of which NV and RV were present in 28.5% and 21.4%, respectively, while SaV and Ast were detected in 3.3% and 2.6%, respectively. Co-infections accounted for 8.5%, mainly among RV and 3 other viruses. There is a significant difference in RV and NV positive rates between vaccinated and unvaccinated groups (p < 0.001 and p = 0.008, respectively). This study contributed to the understanding of the potential impact of rotavirus vaccine on other diarheal pathogens and emphasize the need for further epidemiological studies when the nationwide RV vaccination in Vietnam is implementing.

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Đã Xuất bản

01-08-2022

Cách trích dẫn

Thao, P. T. P. ., Mai, C. T. N. ., Ly, L. T. K. ., Anh, L. T. ., Thanh, V. D. ., Mai, L. T. P. ., Quyet, N. T. ., Mai, T. N. P. ., Thiem, V. D. ., Hien, N. D. ., Anh, D. D. ., & Trang, N. V. . (2022). Prevalence of viral gastroenteritis pathogens among hospitalized children under 5 year of age in the process of introducing the RV vaccine in the routine immunization. Tạp Chí Y học Dự phòng, 32(4), 74–81. https://doi.org/10.51403/0868-2836/2022/686

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