Wednesday, 17 Jul 2019
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Page: 29
Volume 27, Issue 12(197) 2017
The first appearance of measles genotype D8 in Northern Vietnam during 2013-2014 outbreak
Author: Do Phuong Loan, Trieu Thi Thanh Van, Nguyen Thi Mai Duyen, Nguyen Minh Hang, Komase Katsuhiro and Nguyen Tran Hien
Summary:
Measles virus (MeV), a member of the genus Morbillivirus, family Paramyxoviridae, is one of the major causes of vaccine preventable-illnesses and deaths in children in developing countries. From 2013 to 2014, a big outbreak occurred in Vietnam with 9,584 confirmed cases. According to the World Health Organization, in Vietnam, H1 genotype was predominant in the North whereas D8 genotype was predominant in the South. In this study, we examined whether measles D8 genotype circulated in the North of Vietnam in the 2013 – 2014 outbreak by sequencing the region of 450 nucleotides coding for the COOH-terminal 150 amino acids of the N protein and the entire of H gene of one presentative measles strain collected in this period. The results showed D8 genotype detected in the North for the first time and circulated at low frequency (2.4%). The phylogenetic analysis of N gene and H gene showed that Vietnamese D8 strains belonged to “Frankfurt-Main” variant sharing the common ancestor with D8 strains in European countries and distantly related to D8 strains in Asian region. This study provided the evidence of the need to closely monitor the molecular epidemiology to trace to origin of the measles outbreak in Vietnam
Keywords:
measles, D8 genotype, Northern Vietnam
File:
4. Do Phuong Loan.pdf
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Happy New Year 2019! Year of the Pig
The Vietnam Journal of Preventive Medicine wish all readers with healthy, happiness and prosperity in the year of the Pig. Happy New Year 2019
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