Sunday, 24 Feb 2019
Page: 82
Volume XXVI, Issue 12(185) 2016
The situation of antibiotic resistance in Escherichia coli and Klebsiella pneumoniae causing urinary tract infections in pediatric patients in Hanoi, 2015
Author: Pham Dieu Quynh, Hoang Thi Bich Ngoc, Nguyen Thi Anh Xuan, Nguyen Thai Son, Pham Thanh Hai, Nguyen Quang Huy, Le Thanh Hai and Hoang Thi Thu Ha
Urinary Tract Infections (UTIs) prevalence in children ranks the third position following to respiratory and digestion infections. Currently, there is a rapid rise in the number of bacteria strains causing UTIs and simultaneously producing extended–spectrum β–lactamases (ESBLs), which are enzymes with the ability to inactivate β–lactam class of antibiotics, especially carbapnem – one of the novel generation of extended–spectrum antibiotics. In this study, clinical samples were collected from pediatric patients at three hospitals in Hanoi in 2015 for the detection of the most common bacteria strains causing UTIs and resisting to carbapenem, including Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae). The percentages of UTIs isolates, ESBLs producing, phenotype and genotype of antibiotic resistance (ABR) have been showed in our results of isolation, identification, antimicrobial susceptibility testing and molecular experiments. The results confirmed that E. coli and K. pneumoniae have been leading the roots of UTIs and produced ESBLs. The alarmingly high numbers in the resistance to the group of cephalosporins were showed at approximately 100%. In particular, a number of UTI strains was marked as ABR strains to carbapenem with 2.74% (4/146), 3.42% (5/146) and 4.11% (6/146) for ertapenem, imipenem and meropenem, respectively. The findings in phenotype of UTI isolates, with 3/5 cases (60%) in E. coli and 1/1 case (100%) in K. pneumoniae resisting to all three types of carbapenem antibiotic, suppose an association of resisting to carbapenem antibiotics. In addition, we calculated 94.63% (141/149) E. coli and 78.57% (11/14) K. pneumoniae harboring CTX–M gene, which is in agreement with the theory in some recent reports that CTX-M has partly replaced TEM and SHV enzymes as the prevalent ESBL type.
E. coli, K. pneumoniae, UTIs, pediatrics, ESBLs, carbapenem, Hanoi
Download with virtual money of member account.
Happy New Year 2019! Year of the Pig
The Vietnam Journal of Preventive Medicine wish all readers with healthy, happiness and prosperity in the year of the Pig. Happy New Year 2019
Thiết kế web: OnIP™