VJPM
Page: 44
Volume XXVI, Issue 12(185) 2016
Endemic pertussis in Northern region of Vietnam from 1995 to 2014 as a predictor of pertussis outbreak in 2015
Author: Pham Quang Thai, Nguyen Thi Huyen, Duong Huy Luong, Tran Thi Lan Anh, Pham Van Khang, Le Hai Dang and Tran Nhu Duong
Summary:
Pertussis has become a rare disease in Vietnam thanks to the pertussis vaccine. In Vietnam, a sharp increase in pertussis admissions to the National Hospital of Pediatrics (NHP) occurred early in 2015. No similar outbreaks have occurred since 2005. To evaluate the cause of this outbreak, case investigations with standardized investigation forms that collected information regarding demographics, travel, exposure, vaccination and surveillance data analysis were performed. The results were evaluated for demographic trends and risk factors, then linked with a time-series analysis of available pertussis data from 1995 to 2014. In NHP, 204 pertussis patients were investigated, of whom 90% (183) were ≤ 6 months old. Pertussis patients were admitted year-round which peaked from May to July. 74% of the cases came from central Hanoi and nearby provinces. Over 77% of patients had received no vaccine and none were completely vaccinated. Reasons for non-vaccination were postpone due to mild symptom (fever or running nose) (57.5%), waiting for private vaccine (14.2%), or limited vaccination times (11.3%). The results also indicated concerns about postvaccination reactions. Time-series analysis showed pertussis outbreaks occur annually, with larger outbreaks every 3-4 years. The large recent outbreak in NHP could be a result of the accumulation of susceptible individuals, the delay of vaccination and the periodicity of pertussis. To prevent this type of outbreak, it is needed to ensure the highly coverage of routine Pentavalence vaccine and booster DPT at 18 months
Keywords:
Pertussis, National Hospital of Pediatrics, Vietnam, immunization
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