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Page: 27
Volume XXV, Issue 7(167) 2015
Infection and transmission of norovirus and rotavirus in the community- A preliminary investigation
Author: Nguyen Phuong Anh, Vu Thi Bich Hau, Nguyen Cong Khanh, Nguyen Thi Hat, Tran Dac Tien, Do Thi Viet Huong, Dang Duc Anh and Nguyen Van Trang
Summary:
Acute gastroenteritis is one of the most common diseases in children under 5 years of age. Viral agents are recorded as important causes of this disease, of which rotavirus (RV) and norovirus (NV) are responsible for most cases of viral diarrhea in children. In this study, we investigated the cause of diarrhea in children living in the community and viral transmission in their household members. The preliminary investigation was conducted in 82 households with diarrheal children in two districts of Ha Nam during 9 months (3/2014 -12/2014). The fecal samples of children with diarrhea (index cases) and rectal swabs from up to three household members (prioritizing to children) were collected. NV and RV were detected from fecal samples by real-time RT-PCR method, followed by sequencing and nested RT-PCR to determine NV, RV genotypes, respectively. The results showed that the overall prevalence of RV and NV in index cases were 24.4 % and 9.8%, respectively. Among 217 household contacts of 82 diarrheic children, there were 7.8% and 1.8% detected with RV and NV, respectively which is 3-fold lower than that in index cases and mostly without diarrhea symptoms. The common genotypes of NV isolated from diarrheic children and their household members were GI.2, GII.3, GII.4 and GII.SYD. Most of currently circulating rotaviruses in this community belong to G1P[8] and G2P[4]. Transmission of RV among household members was common, especially among children under 5 years of age. Thus personal hygiene while taking care of diarrheal patients should be emphasized to prevent contamination of pathogens between family members
Keywords:
Acute gastroenteritis, rotavirus, norovirus, genotype, transmission
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Happy New Year 2019! Year of the Pig
The Vietnam Journal of Preventive Medicine wish all readers with healthy, happiness and prosperity in the year of the Pig. Happy New Year 2019
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