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Page: 42
Volume XXV, Issue 2(162) 2015
Circulation of Enterovirus 71 subgenogroups in southern Vietnam in 2003–2013
Author: Nguyen Thi Thanh Thao, Vu Thi Huyen Trang, Nguyen Trung Kien, Phạm Mai Thuy Trang, Tran Quoc Khanh, Dang Thi Nguyet, Phan Trong Lan and Vu Thi Que Huong
Summary:
Enterovirus 71 (EV71) is the leading cause of hand, foot, and mouth disease (HFMD). A small proportion of HFMD cases is associated with severe neurological disease in children. Since 1997, a significant increase in both the prevalence and virulence rates of EV71 has been reported in several countries in the Asia-Pacific region. EV71 strains have been isolated from HFMD cases in Southern Vietnam since 2003. In this study, we examined the long-term evolution of the major structural protein, VP1 gene, of 659 EV71 strains collected from 20 southern provinces of Vietnam over an 11 year period (from 2003 to 2013). Phylogenetic analysis reveals the circulation of multiple EV71genotypes, including C1, C4, C5, and B5, during various time periods. Our data indicated two major genotype transitions of EV71 during our surveillance period, as follows: a major transition from the C5 lineage (2003 to 2010) to C4 in 2011 to 2012; and a more recent transition to genotype B5 that was detected during 2012 to 2013. The C4 genogroup, which was detected during 2011 to 2013, caused the largest recorded EV71 outbreak in the region. In addition, our analysis suggests that the ancestors of C4 and B5 were previously detected in other Asian countries, highlighting the frequent introduction of enteroviruses to Southern Vietnam. Our study stresses the need for continued enterovirus surveillance in the region to identify the emergence of novel EV71 and other enterovirus variants. Furthermore, our preliminary study underlines the need for further full genome sequencing to understand whole-genome factors that may induce increased disease severity and transmission of the virus
Keywords:
Enterovirus 71, V71, HFMD, southern Vietnam
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Happy New Year 2019! Year of the Pig
The Vietnam Journal of Preventive Medicine wish all readers with healthy, happiness and prosperity in the year of the Pig. Happy New Year 2019
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