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Page: 23
Volume XXV, Issue 2(162) 2015
Characterization of the VP1 gene from the candidate vaccine strain for enterovirus 71 attenuated vaccine development
Author: Le Thi Luan, Nguyen Van Trang, Vu Thi Bich Hau and Nguyen Dang Hien
Summary:
Hand-foot-and-mouth disease (HFMD) is a common infectious disease caused by a group of enteroviruses, including coxsackievirus (CV) A10, A14, A16 and enterovirus 71 (EV71). However, children infected with EV71 can develop acute neurologic diseases including poliomyelitis-like paralysis, encephalitis, and aseptic meningitis. Many small and large outbreaks associated with EV71 infection have been reported throughout the world since the early 1970s; in particular, outbreaks in Asia-Pacific countries are widespread with many cases of neural complications. There are currently no vaccines or specific therapies for preventing or treating severe HFMD cases caused by EV71. In this study, we present the development of a candidate vaccine against enterovirus 71 from a clinical sample in Vietnam. The candidate vaccine strain was generated through successive cell passages (>40). We also assess the genetic changes in capsid VP1 of thevaccine strain compared to the original wild-type. Several nucleotide and amino acid substitutions occurred after 40 cell passages, yet none of substitution occurs in antigenic region of the VP1 gene. Preclinical study is in progress to further access the safety and immunogenicity of this vaccine strain in different vaccine formulations
Keywords:
EV71, hand-foot-mouth disease, VP1, attenuated vaccine, Vietnam
File:
vjpm_org23_1_2015.pdf
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Happy New Year 2019! Year of the Pig
The Vietnam Journal of Preventive Medicine wish all readers with healthy, happiness and prosperity in the year of the Pig. Happy New Year 2019
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